Alexis Radcliffe is Lois Griffin's rival piano teacher. Radcliffe appears in "Wasted Talent". The two of them happen go to the same gynecologist's office. She often brags of her success just to make Lois angry. But in the end, Alexis loses to Lois.

Although there is no direct credit given for the role, it is believed that Nicole Sullivan, provided her voice.

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